Today over a billion people worldwide enjoy the benefits of a digital lifestyle. But in order to meet the huge challenges faced by society in the next decade, we must find radically new ways for technology to have a much deeper impact on our lives. We will describe the next big wave in technology, which is emerging as the result of advances at the intersection of the biological, physical and information sciences. This will set the stage for innovations which will transform what it means to be human, the very essence of our society and the future of business, beginning with people who are disabled, disadvantaged or disenfranchised.